Skin-Gut Axis
摘要
The skin and gut are closely interconnected organs that engage in bidirectional communication through metabolic, neural, endocrine, and immune pathways, collectively referred to as the skin-gut axis. Both organs host diverse microbiota that influence immune regulation and homeostasis. Disruptions in the gut microbiome, known as dysbiosis, can trigger systemic inflammation and impact skin health, contributing to conditions such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. Evidence suggests that gut dysbiosis and increased intestinal permeability can exacerbate inflammatory skin disorders. The skin-gut axis highlights the influence of diet and the potential therapeutic role of probiotics. Probiotic treatments, both topical and oral, have shown promise in restoring microbial balance and alleviating skin conditions by reducing inflammation and enhancing immune responses. While kefir, a traditional probiotic food, is reported to improve skin parameters, further research is needed to confirm its specific role in modulating the skin-gut axis. Understanding this complex interaction offers insights into managing skin disorders through dietary interventions and microbiota-targeted therapies.