Acne vulgaris is a prevalent dermatological condition affecting a significant portion of the global population, particularly adolescents and young adults. Traditional treatments often face limitations due to side effects and antibiotic resistance. This chapter explores the potential of probiotics, prebiotics, and postbiotics in acne management. Probiotics can inhibit acne-causing bacterial growth and modulate immune responses, while prebiotics support the growth of beneficial bacteria, enhancing overall microbiome health. Postbiotics offer similar benefits without the risks associated with live bacteria. Integrating these biotic strategies presents a promising alternative or adjunct to conventional therapies, potentially improving acne outcomes by addressing symptoms and underlying causes through the gut-skin axis.