We presented a case with gastroparesis from immune checkpoint inhibitor therapy. Work-up of suspected ICI-related enteric neuropathy and gastrointestinal motility dysfunction should include non-invasive measurement of gastric emptying, upper endoscopy, and the serologic workup above for more common endocrine, metabolic, obstructive, autoimmune and infiltrative mimics. Consensus recommendations for ICI-related gastrointestinal motility disorders are not available but society guidelines on diagnostics and treatment of ICI-related autonomic neuropathies may be relevant. The moderate symptoms of our patient were responsive to prokinetic, antiemetic pharmacotherapy and dietary modification; for more severe symptoms or where there is evidence of more generalized neuropathy, the therapeutic role of steroids remains to be clarified.