Based on the difficulties encountered during the construction period of the Sichuan Hejiang Yangtze River Third Bridge with a main span of 507 m—Concrete filled steel tube (CFST) Tied Arch Bridge, technical research has been conducted on the mechanical properties of ultra-high strength CFST (≥ C70), the structural construction of large-span CFST tied arch bridge, and the installation process of the main arch. Based on the research results, this report introduces the calculation method of ultra-high strength CFST, the structural system design of CFST tied arch bridge with a main span of 507 m, the stiffness matching design of the main arch suspension system, the structural design of composite transverse brace, the installation and hanging system of the main arch, and the design of the main arch concrete pouring.