This study examines sustainability communication practices in Ghanaian organizations and proposes a framework for effective sustainability communication in Ghana. The approach included a qualitative analysis of interviews with 15 participants from selected industries to ensure a thorough understanding of the issue. The study identified several critical themes, including having a holistic approach to understanding sustainability, integrating sustainability into business strategy, focusing on a stakeholder-centric approach, utilizing a multichannel communication approach, and aligning sustainability practices with global frameworks. The results led to the development of a sustainability communication framework to enhance the communication of sustainability practices. The framework involves three segments—strategy, engagement, and execution—each with three elements (nine in total). The framework discusses the challenges in Ghana’s socioeconomic landscape and suggests practical recommendations to assist organizations in improving their sustainability communication practices. This study contributes to the knowledge of sustainability communication in emerging markets while providing practical implications for effective sustainability communication.