Endodontic procedures are often complex, challenging, and technique-sensitive, which can increase the risk of clinical negligence and malpractice. Given the rising awareness among patients, it is crucial to understand the legal implications of adverse outcomes, failed restorations, or other complications. Referring patients to a specialist should always be considered if it serves the patient’s best interests. A significant area of patient complaints involves the failure to communicate effectively about the procedure and the lack of informed consent. Inadequate record-keeping is another common issue. However, when treatment is conducted within established guidelines, it becomes difficult for a patient to successfully claim clinical negligence in the event of a failure. This chapter talks about standards of care in endodontics, the different types of errors, addresses potential legal issues and emphasizes how adherence to best practices can help avoid them.