Contemporary dental treatment strives for a holistic approach towards the establishment of functionally favorable and esthetically pleasing dentition and occlusion. Orthodontic and endodontic procedures are frequently performed in tandem to resolve various dental problems. In orthodontic procedures, endodontic treatment may be necessary at various stages, including case preparation prior to the commencement of orthodontic treatment, during the treatment process itself, or upon its completion. This may be essential for addressing root resorption or providing final space resolution at the conclusion of orthodontic interventions. On the other hand, orthodontic techniques for redistribution of spaces or tooth extrusion can facilitate endodontic procedures. Therefore, understanding fundamental principles in integrating endodontics and orthodontics is crucial to optimize the clinical results for every individual patient.