In this chapter, we explore the concept of stigma, with a focus on its implications for individuals with Tourette’s Syndrome (TS). While TS has been clinically defined since the late nineteenth century, how it has been perceived and understood by society has been less explored. We examine how stigmatisation of TS, particularly its symptoms, presents a significant barrier to well-being for those affected. We begin by tracing the historical origins of stigma, from ancient Mesopotamia through to ancient Greek and Roman societies, where individuals were marked with visible signs of shame. This practice evolved into modern forms of social exclusion, wherein specific characteristics, such as those associated with TS, are viewed as signs of difference and weakness. Through a review of stigma theory, including Goffman’s work on the management of “spoiled identities” and Link and Phelan’s stigma-power concept, we highlight how power dynamics and societal norms shape the experience of stigma. Furthermore, we explore the complex relationship between stigma, the medical model, and societal responses to disability, arguing that current treatment models often focus on symptom reduction rather than addressing the social exclusion faced by individuals with TS. The chapter also outlines the role of laws and policies in perpetuating or alleviating stigma, touching on key milestones in the civil rights movement and disability legislation. Finally, we explore potential pathways for reducing stigma, focusing on public awareness, policy change, and community support, emphasising the importance of viewing individuals with TS through the lens of the critical realist approach to disability.