In the pisco industry and those dedicated to packaging liquid products, the capping process is crucial to maintaining product quality during distribution and subsequent sale. This study applied the Six Sigma methodology to evaluate process quality, followed by validation using the Analytic Network Process (ANP) through the “Super Decisions” software. This combined analysis aids in decision-making for process controls. Experimentally, a 20% improvement in capping efficiency and a 15% reduction in closure defects were achieved . Additionally, a 10% reduction in cycle time and a 25% optimization in resource usage were observed. These results highlight the effectiveness of integrating Six Sigma and ANP methodologies to enhance the capping process quality in the pisco industry. The application of these methodologies provides tangible benefits, including increased operational efficiency and improved customer satisfaction. The findings suggest that such an integrated approach can serve as a valuable framework for other industries aiming to optimize their packaging processes and achieve similar gains in product quality and process efficiency.