The paper illustrates the outcomes of a two-year research project on sustainable fashion communication that concluded in an exhibition aimed at raising awareness and calling schools, designers and companies to action in achieving goal 12 of Agenda 2030: Responsible Consumption and Production. To this purpose, the exhibition's narrative path, with its social, cultural, and design objective, brings together ‘denunciation content’ and ‘future trajectories’; it highlights impactful production processes and, at the same time, proposes innovative design and production solutions that participate in the current re-founding of the fashion system. The exhibition was intended to highlight design's ability to propose critical and design visions to the key issues of our time. It, therefore, did not exhibit finished products but was meant to offer experimental inputs, highlight critical issues, and pose questions to establish dialogues and create a cohesive community of users and designers inspired by consumption and design models harmonious with natural and anthropic landscapes. The project was born within the Academic training model which resides the multiple competencies to shape the different communicative forms through which fashion expresses itself. Thus, not only design but also filmography, photography, and costume, a related area often used in major fashion events. “Fashion from destructive to disruptive” was therefore an invitation addressed to students, teachers, companies, and institutions to actively participate in transforming the impact of fashion from destructive to disruptive. Disruptive starting from the development of a new fashion mindset characterized by the proposition of new design canons capable of reshaping the supply chain and its fruition.