This chapter explores the cutting-edge advancements in prosthetic technology embodied by the AIzuHand. The discussion begins with 3D printing technology to create a lightweight and durable chassis, providing exceptional comfort and long-term use for individuals with upper limb amputations. It then presents the sophisticated control systems powered by Artificial Neural Networks (ANN) and Spiking Neural Networks (SNN), which allow for highly adaptive and precise movements, closely mimicking natural hand functions. Furthermore, the chapter highlights the development of a user-friendly smartphone application, offering real-time control and extensive customization options to enhance user experience. In addition, the revolutionary implementation of Virtual Reality (VR) for rehabilitation is examined, showcasing how immersive, interactive environments can significantly improve motor skill recovery and user confidence. By integrating these advanced technologies, the AIzuHand prosthetic stands as a testament to the potential of modern engineering to transform the lives of those with limb loss, setting a new standard in prosthetic design and functionality.