The authors consider the significance of businesses’ ecological responsibility as a manifestation of social commitment, closely intertwined with the economic impact as an existential category of activity and the possibilities of the entrepreneurial community. They stress the necessity of maintaining homeostasis—the factor of civilization’s characteristic constancy, primarily in ecological terms. The authors substantiated the importance of business responsibility in addressing socially significant elements of the architecture of today’s society, closely linked to the ecologization of the existing problem field. The corporate and regional segments of social responsibility are presented within the realm of potential manifestations of economic efficiency. The need for socio-public control is proclaimed as an instrument of disciplining influence and preventing the likelihood of attaining commercial windfalls under eventual conditions of demand for antisocial products and services. In the context of socially significant endeavors, production activity is characterized by a directed agenda, implying the production of environmentally friendly products based on consumer demand while minimizing the likelihood of satisfying requests for antisocial elements in socially alienated goods and services. The fluidity of alienation criteria is acknowledged, contingent upon the national-cultural traditions of different countries. The research concludes with the assertion of a close correlation between aspects of civilization development and the economic efficiency of entrepreneurship, depending on factors of social origin, the potential of which is necessary in the concept of preserving homeostasis of civilizational development.