The desire to attribute to urban planning the ability to interface with the needs and problems of the city and the contemporary territory has meant that in recent years a large part of the scientific literature and urban planning practice has been directed towards the identification of actions that can contribute to resolving the climate issue. Having scientifically ascertained the importance of biodiversity in the process of climate mitigation and adaptation, it has become urgent and indispensable to start a process of safeguarding, valorising and restoring natural ecosystems, both in urban and territorial contexts, identifying the services they produce as the main drivers of biodiversity. The transformation processes determined in the urban sphere by the urban plan can increase the supply of ecosystem services as well as reduce their diffusion in the territory; the plan, even with possible compensation actions, must instead guarantee a high supply of ecosystem services. It is in this context that this contribution is made, which emphasises the role of urban planning in the safeguarding of biodiversity, in particular by referring to the Blue and Green City project, a good example of urban planning that, through the valorisation of Green and Blue Infrastructure, initiates the regeneration of the social system, landscape and environmental system of a sample area in the Piedmont Region through a trans-scalar approach that, by crossing the Vulnerability and Resilience factors with the abundance or lack of Ecosystem Services, identifies the most suitable planning actions for the valorisation of the infrastructures themselves as the main providers of ecosystem services at the various scales of the territorial and urban space.