Pancreatic cancer presents significant challenges in oncology, characterized by aggressive progression and poor prognosis. Surgical resection is the only potential curative treatment, yet it carries substantial morbidity, requiring careful postoperative management. The length of hospital stay (LOS) post-surgery is a critical metric for evaluating clinical outcomes and resource utilization. Both patient-related and organizational factors can significantly influence LOS, therefore understanding factors contributing to extended hospital stay is essential for enhancing patient care. This study builds on previous research on the study of causes of prolonged LOS in surgical oncology and applies a statistical learning approach to investigate factors influencing LOS after pancreatic cancer surgery at the Antonio Cardarelli Hospital in Naples (Italy). The main findings showed how both clinical and organizational aspects of the surgical pathway impact hospital stay duration, thus leaving room for enhancing patient management and quality of care.