In this chapter, the impact of SDOH on an individual’s ability to practice the tenets of lifestyle medicine is discussed. More specifically, an analysis is provided of how vastly different economic conditions, access to quality services, and built and social environments (i.e., conditions that encompass one’s community/neighborhood and include structures, infrastructure, and social context) adversely affect the implementation of lifestyle medicine recommendations for the majority of Americans. Moreover, the roles of inadequate healthcare literacy, support systems, and financial resources are also explored. In short, by critically examining the impact of SDOH on lifestyle medicine, ways to improve chronic disease management across all populations can be elucidated.