There is strong evidence for lifestyle interventions for mental health such as physical activity, nutrition, sleep, social connections, reduction of substance use, and mind–body practices. Replicating findings in randomized controlled trials with adequate sample sizes with participants with diagnosed mental health conditions is needed. Exact neurobiological mechanisms require elucidation. Future directions include providing more personalized and patient-centered lifestyle recommendations, which are challenging given the heterogeneity of interventions in the current research landscape. Lifestyle psychiatry must continue to address systemic barriers, including lack of insurance coverage for specific interventions and allied health services, social determinants of health that limit the ability to sustain positive lifestyle change, and the need for multidisciplinary teams and integration of lifestyle interventions within mental health settings.