The Transition Super-Lab (TSL) is a new approach that considers entire regions as living laboratories organized to accelerate the transformation towards climate neutrality through innovation and cross sectorial synergies on a regional scale. It benefits from a collaborative governance, operates in accordance to systemic transformation principles and utilizes transition enabling methods and tools in order to create added value to cross-sectorial initiatives for economic transformation and to provide feasible solutions to complex regional transformation challenges. The current paper aims to present a high-level understanding of the transition process explaining how the TSL approach is being implemented in the region of Western Macedonia in Greece. Based on the transition model that has been developed as a conceptual framework that defines the overall approach and the guiding principles for managing the transition, the region of Western Macedonia follows a structured path that encompasses various steps. The definition of the vision and goals of change, the coalition building of the stakeholders involved and the development of an action plan for achieving climate neutrality through pilot actions are some of the steps followed by the region for a successful transition.