This chapter is devoted to Africa’s place in the global governance system. Since the 1960s and again since 1990s there have been many attempts by African governments to move away from the traditional global governance, seen as neo-colonial and detrimental to the sovereignty of post-colonial African states. It seems that new global realities give an opportunity for African states to deepen their role in global governance. Meanwhile, Africa is very diverse continent in economic, political, cultural and religious, consisting of different subregions and this makes it difficult for conventional attempts to define a clear African position on global governance. On the other hand, African states strive to act as a single bloc in different international organizations and in the global arena. The level of regional governance is important for African states, often serving as “a window” to the global level for countries in the region. African subregional organizations do not carry the same weight as the African Union. At the same time, they seek to increase their role by emulating and apparently competing with the main regional organization. In Africa there have been several initiatives in the direction toward non-Eurocentric or non-Northern global governance: the New Partnership for Africa’s Development (NEPAD)New Partnership for Africa’s Development (NEPAD) and derived institutions, African Peer Review Mechanism (APRM, Africa’s unique approach to governance), and a growing number of regional and subregional international organizations. However, the author concludes that within the framework of global governance, African international organizations will continue the tendency to borrow external, primarily European, experience. This is facilitated by the economic and political fragility of a number of African states.