The potential of smart technologies to transform tropical disease prevention efforts is immense, offering new opportunities for enhancing public health outcomes in endemic regions. This chapter focuses on integrating digital health innovations, such as mobile health technologies, big data analytics, wearable devices, and the Internet of Things (IoT), to prevent and control tropical diseases. These intelligent solutions facilitate real-time disease surveillance, early detection, predictive modeling, and improved disease management. By providing tools for continuous health monitoring, particularly in remote areas, these technologies enable timely interventions and better healthcare delivery. The application of IoT technologies, for example, enhances data collection from vulnerable populations, helping inform public health strategies and response efforts. Similarly, wearable devices and health sensors contribute to the early detection of symptoms and proactive disease management. The chapter also highlights the significance of automated insect control systems and smart sanitation technologies. Integrated with real-time monitoring and data analytics, automated vector management tools offer sustainable solutions for controlling vector-borne diseases. At the same time, innovative sanitation and water purification systems are crucial for tackling waterborne infections. However, to maximize the impact of these innovations, it is essential to address challenges related to digital health equity, infrastructure, and stakeholder collaboration. By fostering partnerships and promoting widespread adoption of smart technologies, these innovations can revolutionize the fight against tropical diseases, ensuring improved health outcomes for vulnerable populations in tropical regions.