The water disinfection process increases DBPs through chemical reactions of organic and inorganic substances present in the water. Developed or developing countries are currently grappling with secondary pollutants such as disinfectant by-products. Notably, DBPs are becoming an emerging concern by increasing the rate of eco-toxicological impact on a person’s health and water ecosystem. This review article explores the presence of DBPs in the urban water cycle, its hazardous health impacts, various treatment methods for disinfectants, potable water treatment plants, excessive disinfectant removal techniques, and domestic, wastewater treatments. Internal and external factors are responsible for the effects of DBP in surface water systems. The impacts of DBP are observed in the urban water cycle and individuals who is associated with swimming associations, such as swimmers, pool workers, and sometimes children in swimming classes. This has raised serious concerns about respiratory and skin diseases in swimmers. Additionally, the review addresses the regulatory frameworks and standards for DBP levels in drinking water, highlighting the need for stringent monitoring and compliance to safeguard public health. The future perspective of this research involves developing predictive models for assessing the mitigation, significance, assessment, removal, and impact of DBPs on an aquatic ecosystem. These models also highlight the importance of DBP removal methods in terrestrial and atmospheric environments, emphasizing a comprehensive approach to managing DBPs in all environmental contexts.