Skin cancerSkin cancer is the most common malignancy in the United States. While skin cancerSkin cancer occurs less commonly in skin of colorSkin of color (SOC), it is associated with increased morbidity and mortality when compared with skin cancerSkin cancer in non-Hispanic Whites. Given the anticipated shift toward a more diverse population in the United States, with an expected 50% of the population having SOC by 2060, it is crucial for physicians to gain familiarity with the diagnosis, treatmentTreatment, and prevention of skin cancerSkin cancer in all skin tones. This chapter reviews special considerations when treating patients of diverse skin tones with Mohs surgeryMohs surgery.