MelanomaMelanoma is a clinically and biologically diverse malignancy for which complete surgical excisionSurgical excision offers the only chance for cure. Current guidelines for surgical excisionSurgical excision margins are based on consensus recommendations, and clear, evidence-based data to guide the surgeon in each case is limited. Mohs micrographic surgeryMohs micrographic surgery (MMS) offers the surgeon the ability to assess 100% of the surgical margin, far better than margins evaluated with the standard bread-loaf sectioning technique. Immunohistochemical stainsImmunohistochemical stains such as MART-1 allow for the reliable identification of melanomaMelanoma in frozen sectionsFrozen sections with lower rates of local recurrence and longer melanomaMelanoma-specific survival at least as good as standard excision with traditional margins.