Contemporary mobility systems are often regarded as key factors contributing to the appeal and to the economic growth of urban areas. Many studies have shown that High-Speed Rail (HSR) is an innovative transportation system able to contribute to the economic development of areas, for instance by modifying land value or boosting tourism. However, the role of High-Speed Rail in affecting tertiary education choices has not yet been explored in scientific literature. High-Speed Rail improves territorial connectivity and can give students the opportunity to explore more education alternatives to meet their ambitions. The inflow of university students enhances the high-skilled human capital and competitiveness of areas, while depleting it in the areas of origin, which in Italy are primarily southern regions. In this paper, the higher education system and the internal student mobility in Italy is described and literature regarding transportation and student mobility is reviewed. The paper then proposes two models that can be used to study the effect of HSR for tertiary educational choice.