This study aims to examine one of the variables of a city’s livability, which enhances thermal stress and minimizes human pressure, and improve health and well-being. The study also delves into establishing the link between these variables and the sustainable development goals (SDGs), mainly goals 3, 11, 12, and 13 to maintain an efficient community and enhancement through surrounding air quality reduction. In addition, uncover the factors that influence inhabitants’ default behaviours and strategies to break free from unsustainable habits, especially in the COVID-19 age. Scientists confirm that human behaviour, non-resilient cities, and urban areas, in addition to CC, are the main reasons for fast spreading. The methodology is centred on two approaches (qualitative and quantitative). The first introduces the importance of the topic, analysis, and adopted questionnaire that is divided into two important parts, while the second approach simulates the case study (a 150-square meter apartment in a selected urban representing a hot climate region, like the city of Giza, Egypt), by exploiting ENVI-Met and Design Builder software to validate the effectiveness of the applied Trombe Wall (TW)—a thermal insulation system. This technique acts as a passive strategy for adjusting thermal comfort (air temperature, relative humidity, air speed, and mean radiant temperature) in interior spaces in addition to CO2 emissions reduction to adjust human stress through the year (summer and winter). Moreover, it has been used to minimize the cooling load, consequently minimizing energy consumption and mitigating CO2 emissions. In addition, we compare the simulation results with those obtained from the questionnaires to reach comfort levels and standards yet help in enhancing human behaviour inside interior spaces. Results show that the TW can reduce energy consumption for cooling-heating by up to 30% in residential buildings while mitigating the annual CO2 emissions by approximately 455 kg in addition to a substantial reduction in solar heat gain estimated by more than 50%. The outcome is considered a part of green infrastructure that engages the exterior envelope with the interior and adjusts the stress level of humans inside space. This strategy can assist in fostering the city’s sustainability and resilience by recognizing the power of positive change in residential spaces and encouraging every individual to contribute to reaching near or net zero.