The evolving market landscape is significantly influenced by various factors, such as European Green Public Procurement (GPP) policies, widespread adoption of voluntary green building evaluation programs, and an increasing emphasis on reducing reliance on raw materials through the principles of the circular economy. As a result, there has been a notable surge in demand for bio-based and sustainable building materials. This study aims to explore possible avenues for the reuse of biological waste materials, focusing particularly on wood waste derived from the wood industry, to develop innovative and environmentally friendly building materials in line with circular economy principles. While previous studies have demonstrated the feasibility of reusing such waste to create new building components, current trends reveal a widespread use of synthetic resins as binders, posing challenges to achieving true circularity and raising concerns about volatile organic compound (VOC) emissions harmful to human health and well-being. Through rigorous laboratory investigations, this study emphasizes the feasibility of integrating wood waste with clay, presenting a range of promising applications and formulating innovative bio-based materials for the construction sector. The initial results show the transformative potential of utilizing underutilized waste as valuable “nutrients” for industry, facilitating a continuous flow of material value within a circular paradigm, and promoting the ethos of material reuse and recyclability for extended periods. Furthermore, these materials could be particularly useful in the context of post-emergency architecture, where the need for rapid, sustainable, and cost-effective solutions is critical for the reconstruction and restoration of communities affected by natural disasters or catastrophes. The adaptability and availability of these materials could offer practical and resilient solutions to address the challenges of architecture in post-emergency contexts. While the focus and reference of the study are on the Sicilian context, the results have transferable implications for other regions with similar industries, such as those related to dried fruits. This could catalyze the emergence of new business models that either replace or integrate existing frameworks while simultaneously nurturing skills and promoting new roles within supply chains aimed at enhancing the circularity of natural resources.