Climate change stands as the most significant environmental threat currently facing planet Earth. The global average temperature has increased by 1.2°C since the preindustrial era, reflecting its impacts on the overall climate. This rise has led to a major increase in the frequency, intensity, and duration of extreme weather events. Similarly, attention has focused on the Urban Heat Island (UHI) phenomenon, resulting in the warming of cities due to human activities and urban configurations. With the ongoing growth and urbanization of cities, it is imperative to transform and address the design of urban spaces to accommodate the population and tackle climate challenges. Urban adaptation of streets and the development of new urban spaces are aimed at achieving thermal comfort. While indoor spaces primarily rely on air temperature to establish comfort, outdoor comfort depends on various variables, and the combination to achieve an adequate level is extensive. Additionally, the literature focuses on investigating the UHI effect and urban space adaptation using methodologies based on Surface Energy Balances (SEB). These SEBs consider key climate variables and heat flows but are limited in detecting the UHI as they do not account for anthropogenic heat. To address this limitation, this work proposes a calculation methodology capable of integrating anthropogenic heat as a fundamental component to understand and quantify the intensity of the phenomenon. The methodology begins with the analysis and modelling of the initial state of an urban canyon. Its intervention is justified through the monitoring of key climate variables defining the canyon’s microclimate. Using modelling, simulation, and results from the ENVI-met software, a co-simulation process based on SEB and real anthropogenic measurements is developed. The intervention is validated through theoretical and experimental foundations of the Heat Load Comfort Index (COMFA), sharing a comprehensive sensitivity analysis. The methodology has resulted in the improvement and adaptation of the studied urban canyon to create a comfortable space. The adaptation of the urban canyon, considering vegetation, the restriction of the circulation of vehicles, and pavements that absorb less heat energy, has managed to improve the COMFA index by 30%. This innovative approach aims to fill gaps in previous experiences and contribute to understanding and managing the UHI in urban contexts affected by climate change. The result translates into the implementation of innovative solutions and the study of their impact on urban comfort to achieve climate change adaptation.