The River Godavari, spanning over 1,465 km, has been both a source of livelihood and a focal point for religious worship for centuries. However, despite its sacred status, human-induced pollution, including the disposal of religious offerings and industrial waste, continues to degrade its water quality. Various government and community-driven initiatives have aimed at reversing this trend, but persistent issues like untreated sewage, agricultural runoff, and deforestation along the river’s banks demand further action. This review critically evaluates the socio-cultural impact of worship activities on the river, while also assessing the effectiveness of environmental policies aimed at its conservation. Quantitative data on pollutant levels and the socio-economic challenges faced by dependent communities underline the urgent need for sustainable practices. The chapter suggests a holistic approach that integrates religious sentiments with environmental responsibility, with recommendations for policy interventions that focus on awareness and long-term restoration efforts. Incorporating religious stakeholders into conservation efforts is crucial for the river’s future.