Cytokine storm, endothelial cell and complement activation, hypercoagulability and NETosis are implicated in the process of worsening in patients with COVID-19. Predisposing risk factors for severe COVID-19 are male gender, underlying cardiovascular disease or cardiovascular risk factors (including diabetes, high blood pressure, obesity, and advanced age). Venous thromboembolism is also a risk factor for deterioration of COVID-19 and is independently related to mortality. The VAS foundation (VAS-European Independent Foundation in Angiology/Vascular Medicine) has presented an integral strategy for the management of patients with vascular diseases or cardiovascular risk factors based on the Prevention of infection by SARS-CoV-2, the Detection of patients with COVID-19 at high risk of disease worsening and the Anticipation of vascular complications related to cytokine storm and hypercoagulability. The antithrombotic agents are of major importance for the prevention of COVID-19-associated thrombosis as well as for the prevention of disease worsening particularly in vascular patients and in patients with cardiovascular risk factors. Access to and the status of, the public healthcare system, socioeconomic status, and living conditions play crucial roles in determining individuals’ vulnerability to the SARS-CoV-2. The acknowledgement of the negative impact of the socio-environmental predictors on the risk of SARS-CoV-2 infection and the negative outcome of patients with COVID-19 and particularly for those with cardiovascular disease or cardiovascular risk factors or cancer is of major importance for the improvement of the provided care at the level of the primary healthcare structures using the most modern technologies (i.e. telemedicine).