Chronic venous disease (CVD) is a very common disorder affecting more than 50% of the adult population. The severity is classified according to the clinical, etiological, anatomical, and pathological (CEAP) classification, varying from C0 to C6. CVD is a progressive disease, which means that the patient will evolve to a higher C-class over time. Having a venous leg ulcer is the end-stage of the disease. The underlying pathophysiology is an inflammatory reaction in the vein wall sustained by valve incompetence and reflux in the veins. This results in venous hypertension. Symptoms include “having heavy legs,” pain, sensation of swelling, burning sensation, night cramps, itching, sensation of pins and needles, and having restless legs. Risk factors are “having a positive family history,” age, gender, lack of regular exercise, obesity, and prolonged standing. CVD has a higher prevalence in Western countries compared to others; however, after correcting for risk factors, the differences diminish. The disease has an important influence on the patient’s quality of life. The burden of CVD care and treatment is enormous, consuming approximately 2% of national healthcare in Western societies.