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This study investigates the synthesis of gold nanoparticles (AuNPs) using different reducing agents, including glutamate, cysteine, catechin, ellagic acid and walnut extract, with Au+ and Au3+ precursors. The optical properties and coloration of the resulting AuNP suspensions were analyzed to distinguish distinct red and blue-violet hues indicative of colloidal nanoparticle formation and stability. On the one hand, cysteine showed a reduction of both Au+ and Au3+ obtaining violet suspensions, while ellagic acid, catechin and ethanol extract of pecan nut showed potential as a green synthesis route attributed to their antioxidant properties by obtaining stable wine-red suspensions. UV-Vis spectroscopy and SEM characterization confirmed the formation of nanoparticles. The results reflect an advance in the development of nanomedicine systems aimed at improving treatments for acute lymphoblastic leukemia.

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Synthesis of Gold Nanoparticles Using Extracts or Biomolecules Contained in Pecan Nut for Potential Applications in the Treatment of Acute Lymphoblastic Leukemia

  • 会议论文

  • 发表日期：

    2025年

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  • Joselinne Alicia Valdez Mendoza,
  • German Hoyos Conteras,
  • América Jolette Ortiz Castillo,
  • Maricruz Rocha Rubio,
  • Jazmín Cristina Stevens Barrón,
  • Christian Chapa González

摘要

This study investigates the synthesis of gold nanoparticles (AuNPs) using different reducing agents, including glutamate, cysteine, catechin, ellagic acid and walnut extract, with Au+ and Au3+ precursors. The optical properties and coloration of the resulting AuNP suspensions were analyzed to distinguish distinct red and blue-violet hues indicative of colloidal nanoparticle formation and stability. On the one hand, cysteine showed a reduction of both Au+ and Au3+ obtaining violet suspensions, while ellagic acid, catechin and ethanol extract of pecan nut showed potential as a green synthesis route attributed to their antioxidant properties by obtaining stable wine-red suspensions. UV-Vis spectroscopy and SEM characterization confirmed the formation of nanoparticles. The results reflect an advance in the development of nanomedicine systems aimed at improving treatments for acute lymphoblastic leukemia.