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A microfluidic platform based on organ physiology has been developed to design biological systems that simulate specific environments, such as liver tissue. This custom-designed system incorporates a dual-inlet-outlet bioreactor, equipped with peristaltic flow and adjustable velocity variations to regulate the luminal flow rate. The model was designed in Solidworks and simulated in SolidWorks Flow Simulation, with the universal physical properties of water including an isothermal Newtonian liquid, density of 1000 kg/m3, viscosity of 0.889 mPa, a continuous flow rate of 7 ml/h and atmospheric pressure, the material was photocurable resin (Anycubic), with elasticity modulus (E) 1.2 GPa and Poisson’s ratio 0.3. In addition, the system effectively facilitates the distribution of nutrients in the liver tissue model, transferring substances into the chamber through the channels.

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Design and Characterization of an Organ-on-Chip (OOC) and Microfluidic System for Liver

  • 会议论文

  • 发表日期：

    2025年

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  • Ricardo Legorreta-Atienzo,
  • Esmeralda Zuñiga-Aguilar,
  • Odin Ramirez-Fernandez

摘要

A microfluidic platform based on organ physiology has been developed to design biological systems that simulate specific environments, such as liver tissue. This custom-designed system incorporates a dual-inlet-outlet bioreactor, equipped with peristaltic flow and adjustable velocity variations to regulate the luminal flow rate. The model was designed in Solidworks and simulated in SolidWorks Flow Simulation, with the universal physical properties of water including an isothermal Newtonian liquid, density of 1000 kg/m3, viscosity of 0.889 mPa, a continuous flow rate of 7 ml/h and atmospheric pressure, the material was photocurable resin (Anycubic), with elasticity modulus (E) 1.2 GPa and Poisson’s ratio 0.3. In addition, the system effectively facilitates the distribution of nutrients in the liver tissue model, transferring substances into the chamber through the channels.