Nanoparticles (NPsNanoparticles (NPs)) have been acclaimed as a major advancement in agricultureAgriculture for enhancing crop productivityCrop productivity and maintenance. The NPsNanoparticles (NPs) interact with plantPlant systems, and this complex interaction depends on both NPsNanoparticles (NPs) and plant speciesPlant species.The characteristics associated with metal-based nanoparticlesNanoparticles (NPs), such as size, charge on the surface, and environmental condition are the significant factors in their transport and uptakeUptake via leaves or rootsRoot as well as positive or negative impacts on the plantsPlant. NPsNanoparticles (NPs) accumulate in the plantPlant's upper and lower sections before being transported to different tissuesTissue via symplastic and apoplastic routes. The interaction between plantsPlant and NPsNanoparticles (NPs) is a critical topic in nanotechnologyNanotechnology developmentDevelopment , however, their mode of absorption and the relationship between plantsPlant and the environment is in question. This review provides an overview of the NPsNanoparticles (NPs) uptakeUptake via foliar and rootRoot, and different physiological obstacles, and factors influencing their uptakeUptake as well as its movement routes via xylemXylem andXylem and phloem transport phloemPhloem. Furthermore, key factors that restrict NPsNanoparticles (NPs) uptakeUptake including wax deposits on the surfaces of leaves, leaf structureStructure, atmospheric factorsSoil micro-biome, soil microbesSoil microbes, root exudatesRoot exudates, and the chemical and physical characteristics of NPsNanoparticles (NPs) are covered. The significant difficulties in each discipline are extensively reviewed and future research directions are highlighted.