In the twenty-first century, tuberculosis (TB) is a treatable illness. Still, the 2022 TB Report of the World Health Organization states that it remains the thirteenth leading cause of death worldwide, the second leading cause of death from an infectious disease (apart from COVID-19). Comorbidity between TB and mental illness is common, and we know that this relationship is bidirectional. People with serious mental illnesses and addictions are at elevated risk of infection with TB, and people becoming infected with TB are at elevated risk of developing a mood disorder, some of which may be at least partly related to the drug treatments for TB. Failing to address the social determinants of TB means that those who survive acute infection with TB remain at risk for poor health outcomes, which include re-infection with TB and elevated mortality rates, and this indicated the need for integrated care in the holistic management of TB. An integrated approach to illness education, support, and accessible treatment in the community may serve to mitigate against the combined effects of psychiatric comorbidity on adherence and treatment outcomes in the management of TB.