Many medical students find psychology challenging and this can have a negative impact on their engagement with the subject. This chapter will explore some of the key barriers that medical students might encounter that may explain why they find psychology difficult or inaccessible. In particular it will consider how the lack of familiarity and exposure that students have with the subject may play a pivotal role. Psychology is very much an interdisciplinary subject, and this is a strength that can be exploited by linking the subject to concepts that medical students are likely to be more familiar with. This linking should help students to understand what psychology is and to appreciate how and why it holds such value in medical education. Some practical examples are presented to illustrate its value, for example introducing students to the concept of uncertainty which is prevalent in medicine yet frequently an unexpected and uncomfortable concept for them. It is important that students have opportunities to actively apply and discuss their psychological knowledge rather than simply learning the theoretical concepts. Ideas to promote active engagement such as authentic and relatable learning material, opportunities for experience sharing and including practical activities they can engage with can all promote the practical and applied nature of psychology and increase medical students’ engagement with the subject by making it more accessible to them.