Climate change, urbanization, and overpopulation are of a global concern that can hamper smooth food supply chain and security worldwide. There is an extreme need to enhance food security through increased production and improved produce quality that meets consumer demands for preferred taste and nutrition. Fruits and vegetables are rich sources of nutrition, minerals, taste, and essential phytochemicals. Conventional breeding techniques in fruits and vegetables require longer periods to develop new desirable cultivars. Therefore, it is pivotal to improve fruit and vegetable crop plants with the new robust and precision breeding techniques including genome editing. Gene editing refers to the modification of gene sequences either replacement, deletion, or insertion of foreign DNA segments. Currently, genome editing tools such as ZFNs, mega nuclease, TALENs, and the advanced CRISPR/Cas9 technologies are being explored advancing fruit and vegetable production and quality. The integration of gene editing techniques has been globally recognized for sustainable crop production and quality traits enhancement e.g. color and aroma, shelf life, and biotic and abiotic stress resilience augmentation. This advanced kind of breeding approach has saved time and sped up the breeding processes. These target genome editing crop improvement techniques carry a positive impact on human health in mitigating malnutrition. However, these techniques are expensive and require technical expertise. There is also a need to provide awareness among people to resolve myths and concerns relevant to genetically modified crops, as these innovative techniques have remarkable potential for agricultural food chain sustainability at present and beyond.