At first glance, fluid leakage through fault zones and induced seismicity may look like different issues dealing with the different risks that they put on the management of a CO2 storage project in a deep reservoir. Leakage risk concerns the loss of caprock integrity caused by CO2 penetrating faults cutting through the reservoir and the caprock, thus located at and above the injection reservoir depth. Seismicity is in general localized deeper on faults, mostly disconnected from the injection reservoir and rooted into the upper basement rocks. Nevertheless, this review highlights that workflows integrating fluid leakage and induced seismicity together should be more beneficial to the management of CO2 storage projects, first because observations show earthquakes associated to leakage in caprocks and downward pressurization of faults favors induced seismicity in the basement.