This chapter of Women Scientists in American Television Comedy: Beakers, Big Bangs and Broken Hearts concludes this volume by highlighting the significant role humor in TV comedies plays in shaping public perceptions of women scientists and promoting STEM careers among young women. The analysis of 47 episodes from Never Have I Ever, The Big Bang Theory and Zoey’s Extraordinary Playlist revealed that irony and satire were the most common humor types used. These forms of humor often criticized male characters and patriarchal structures, aligning with feminist humor that challenges traditional gender stereotypes and power dynamics. The chapter emphasizes that humor makes science relatable and enjoyable, potentially increasing engagement with scientific concepts. The study acknowledges its limitation to Western, specifically American, cultural contexts and suggests future research explore humorous portrayals of women scientists in non-Western media. It also calls for empirical studies to assess how TV comedies influence audience perceptions and behaviors regarding science. The findings demonstrate that humor in TV comedies can both reinforce and subvert gender stereotypes, using irony, satire and ridicule to challenge misogynistic attitudes and highlight the challenges faced by women scientists. Ultimately, the study underscores the importance of diverse and complex representations of women in STEM, showing that humor can be a powerful tool for social change and empowerment in science communication.