This chapter identifies and explains technologies and technologically supported approaches for implementing interoperability solutions. These technologies and approaches are discussed with respect to communication, coordination, cooperation, and collaboration (4C’s) of systems. Their possibilities are highlighted on various levels of the automation pyramid (ISA-95ISA-95 architecture (*). Given the constant evolution of technologies, this chapter does not intend to deliver a comprehensive overview of the state-of-the-art, but rather discusses selected technical possibilities enabling the 4C’s at all levels of the automation pyramid.