Assembly is an important part of the manufacturing process, and the quality of assembly directly affects the performance of the product. In order to improve the quality of product assembly, it is necessary to carry out a reasonable design of the assembly process first. In view of this, this chapter first analyzes the progress and current situation of assembly process design. Secondly, it studies the intelligent design method of assembly process based on knowledge graph. Finally, it combines the assembly case of an aero-engine compressor rotor component to verify and illustrate the relevant technical methods.