This research investigates the impact of a remote working setting on soft-ware engineers’ (SEs’) well-being, as well as explores the potential of Positive Psychology to manage challenges and enhance their overall well-being. Software engineers (SEs) face various challenges in their daily routine, among which are to meet deadlines, fix coding problems creatively and on time, deal with non-coding related tasks, be as productive as possible, and deal with clients. All these provoke a high amount of pressure, leading to high rates of stress, anxiety and self-doubt, which consequently reduce their motivation and affect their overall performance. The recent and abrupt shift to a Work-From-Home (WFH) model, due to COVID-19 restrictions, accentuated these challenges. Meanwhile, it introduced apprehension related to the adaptation to the new work setting while managing isolation and sustaining productivity. Despite the available research on SEs’ well-being on a traditional work setting, there seems to be limited research on the specific challenges as well as promising interventions for their overall well-being and resilience while working remotely. This study, aims to address the gap and explore the potential of Positive Psychology Intervention as a tool that could positively contribute to their productivity, motivation, resilience, personal and professional balance and their overall well-being, while working from home. The Systematic Literature Review examines the challenges Software Engineers face daily while WFH, in terms of performance, productivity, motivation, and well-being. Following the aforementioned WFH challenges, this study explores the potential applications of Positive Psychology Interventions, as well as organizational practices to enhance their overall well-being and performance.