Undoubtedly, even though the blockchain constitutes a big opportunity for the organizations of all the industries, the virtues of this technology cannot be harnessed without an adequate level of managerial skills. Despite the emphasis that has been given on the impact of top management support on blockchain adoption throughout the literature, there is shortage of research papers exploring the blockchain-related knowledge that the technology managers should obtain. This study comprises an initial attempt to cover this literature gap by explicating the adoption of blockchain through the lens of the five technology management processes proposed within the Gregory’s framework (identification, selection, acquisition, exploitation, protection). By performing a literature review, this research paper detects twenty-three critical strategic questions and segments them into the five processes of technology management. In addition, regarding every single question, it presents possible answers deriving from the bibliography. From the academics’ side, this study suggests a synthesis of multiple issues pertaining to the wide topic of blockchain adoption, while it comprises the first step to develop the theory of the necessary blockchain-related knowledge from the angle of technology managers. From the practical point of view, it informs technology managers about several questions that they will have to respond to during the forthcoming blockchain-based era and instruct them on how to make the most suitable options. Being informed about diverse issues around blockchain implementation, the technology managers can considerably contribute to the success of enterprise blockchain projects.