This chapter discusses the increased formation of platform networks and reflects on the implications on platform competition and regulation from an information systems perspective. The development is strongy driven by recent advances in artificial intelligence (AI) platforms such as the assistants from Alexa from Amazon or ChatGPT from OpenAI. Both yield access to other platforms in the areas of smart home, tourism, and many more. Although these networks of digital platforms provide new opportunities for value creation, their less centralized topology raises challenges governance and regulation. Contrary to a single-platform model where a platform provider determines the platform’s partner and service strategy, platform networks emerge rather bottom-up when third-party source platforms register their functionality in a host platform’s registry. Among the relevant effects are information asymmetries among the interconnected platforms as well as higher-order externalities, such as cross-platform network effects and polyadic complementarities. These effects influence competitive advantage, and highlight trade-offs between platform regulation and potential value creation through sharing of data. Following the Digital Service Act (DSA) and the Digital Markets Act (DMA) managing the dynamics in networked platform ecosystems requires a balance between openness and data privacy as well as between ex ante and ex post regulation.