This chapter explores the innovative integration of Unani therapy with Ayurveda, Yoga, and traditional biotechnology to form a holistic approach to healthcare. Grounded in ancient wisdom and philosophies, Unani medicine, Ayurveda, and Yoga are combined with traditional biotechnological practices to create a comprehensive system addressing the interconnectedness of the body, mind, and spirit. The chapter discusses the theoretical foundations of each system and outlines the principles guiding their integration. It highlights the synergy between Unani, Ayurveda, and Yoga, emphasizing the personalized and holistic nature of the approach.