This study investigates the resilience and disparities characterizing Ukrainian regional labor markets between 2019 and 2021. Employing a multidimensional approach, it combines taxonomic analysis and integral assessment to explore how economic, demographic, social, and infrastructural factors interact and influence regional labor market outcomes. The findings highlight significant regional disparities. Kharkiv, Lviv, and Dnipropetrovsk emerge as leaders, exhibiting resilience through economic diversification, strong infrastructure, and skilled workforces. Conversely, Donetsk, Volyn, and Ternopil demonstrate the lowest performance due to factors like military conflict, overreliance on agriculture, and weak infrastructure. The study underscores the importance of economic diversification, infrastructure development, and a skilled workforce for fostering robust and adaptable regional labor markets. It highlights the capacity for adaptation and resilience, exemplified by Lviv and Dnipropetrovsk’s advancements. Conversely, persistent structural issues and limited investment hinder progress in regions like Donetsk, Volyn, and Ternopil, limiting their ability to adapt and improve. The effectiveness of the employed methods is confirmed. Taxonomic analysis facilitates the identification of regional trends, while integral assessment provides insights into the interconnectedness of factors influencing labor market resilience. In conclusion, this research offers valuable insights into the resilience and disparities within Ukrainian regional labor markets. The employed methods prove to be effective tools for analyzing labor markets and pinpointing crucial factors for regional economic policy development, fostering resilience and promoting a more balanced regional landscape.