The present chapter reviews the main tectonic episodes affecting the Northern Red Sea-Gulf of Suez (NRS-GOS) rift. This chapter comprises four main divisions, including: the unravelling the inherited tectonic trends using regional potential surveys, Mesozoic, Cenozoic and present-day tectonics. Potential surveys are portrayed via gravity and magnetic data using advanced enhancement techniques in order to delineate the deep seated tectonic trends (e.g., Tethyan and Najd Fault Systems). These trends played a vital role in shaping the present day geometry of the NRS-GOS rift. Also, Mesozoic and Cenozoic tectonics related to the Tethys rifting and convergence as well as Red-Sea-Gulf of Suez rifting is inferred on the basis of key outcrops from Cairo-Suez District, the western margin of the Gulf of Suez rift (e.g., Wadi Araba inverted basin, Gharamul-Dara Block) and the NW Red Sea (e.g., Gebel Duwi Block). Finally, Synthetic Aperture Radar (SAR) data are used to monitor recent activity along the major faults at the NRS-GOS rift.