The use of synthetic fertilizers and agrochemicals has been instrumental in meeting global food demand. However, conventional application methods raise concerns regarding nutrient losses, environmental pollution, and inefficient resource usage. In the pursuit of sustainable agricultural practices, the innovative technique of fertigation has emerged as a promising solution. This chapter provides an in-depth examination of fertigation, encompassing its historical development, underlying principles, and diverse methods employed in its implementation. Fertigation, a portmanteau of “fertilization” and “irrigation,” involves the precise application of nutrients and agrochemicals through irrigation systems. This approach offers several advantages over traditional broadcasting methods, including reduced nutrient wastage, enhanced nutrient uptake efficiency, and minimized environmental impacts. The concerns related to synthetic fertilizer use, such as water pollution and soil degradation, have prompted researchers and practitioners to explore fertigation as an eco-friendly alternative. This chapter examines the congruence of fertigation with precision agriculture techniques, exploring the role of sensor technologies, automation, and data analytics in ensuring the accurate delivery of nutrients based on plant requirements. Moreover, the potential synergies between fertigation and organic farming practices are discussed, offering insights into holistic approaches that combine synthetic inputs with environmentally conscious methodologies. While the prospects of fertigation are promising, challenges related to infrastructure, cost-effectiveness, and farmer adoption remain significant. This chapter addresses these hurdles and proposes strategies to promote the widespread adoption of fertigation across various agricultural contexts. Additionally, it contemplates the role of policy frameworks and incentives in catalyzing the transition towards more sustainable nutrient management practices. In conclusion, this chapter provides an exhaustive overview of the concept of fertigation as a transformative approach in the realm of synthetic fertilizers and agrochemicals. Through a critical evaluation of its advantages, hurdles, and potential, this chapter contributes to a deeper understanding of how fertigation can revolutionize modern agriculture, mitigate environmental concerns, and pave the way for a more sustainable and food-secure future.