Carl Gustav Carus must be considered the most important medically oriented psychologist of the first half of the nineteenth century. With reference to anthropological findings and on the natural philosophical basis of the genetic method, he understood the development of the psyche from the egg cell as a gradually growing process in the interaction between the inherent inner dynamics and the surrounding environment. The unconscious (or unconsciousness) that is gradually modeled through the course of life becomes decisive for concrete life, thus resulting in an organic and genetic psychology for Carus. The as form established but yet unspecified unconscious plays an important role in this process, essentially determining the course of the unfolding life, specified and controlled by the gradually built-up conscious, thus resulting in an organic whole. With increasing emphasis, Carus postulates a divine idea in the unfolding of nature and human “Darleben.” But on the other side the new observations on epigenetics are in line with Carus’ thoughts.