The reliance on vegetables in daily life is significant, primarily attributable to their nutritional value. With the exponential growth of the population, there is a corresponding rise in the demand for food rich in nutritional value. Vegetable crops, characterized by their high nutrient content, serve as significant alternatives for addressing the dietary needs of an expanding population. Traditional approaches have played a crucial role in enhancing the yield of vegetable crops, improving their nutritional quality, and increasing their resilience to biotic and abiotic stresses. However, numerous limitations are associated with these methods. Researchers developed genome editing tools to address these challenges and selected them for the improved and more dependable outcomes. Utilizing these tools has significantly expedited the breeding process, thereby conserving time, attributable to their inherent features, which include user-friendliness, specificity, versatility, and simplicity. Genome editing has made transgenic plant development significantly more precise and accessible than conventional breeding, allowing the targeted introduction of small indels or replacement of mutations, including single-nucleotide changes. Various genome editing tools have been employed to enhance the environmental sustainability, climate resilience, productivity, nutritional value, safety for consumption, and pathogen resistance of essential vegetable crops. This chapter examines the efforts, applications, and future possibilities of CRISPR/Cas-based methodologies in vegetable cultivation, highlighting their potential to enhance sustainable crop productivity.