This comprehensive review explores recent advancements in airway stent technology, focusing on three-dimensional-printed and biodegradable stents for central airway obstruction (CAO). The chapter discusses the design and manufacturing process of customized three-dimensional-printed stents, highlighting their potential to address complex airway geometries and patient-specific needs. Clinical applications and outcomes of these personalized devices are examined, along with current challenges and future directions. The review also delves into biodegradable airway stents, detailing various materials and degradation mechanisms. Preclinical and clinical studies demonstrating the feasibility and biocompatibility of bioresorbable stents are presented. The integration of drug-eluting properties with both three-dimensional-printed and biodegradable stents is highlighted as a promising avenue for future development. While these innovative approaches show potential for improving CAO management, the chapter acknowledges the need for further research and regulatory considerations before widespread clinical adoption. The review concludes by emphasizing the ongoing efforts to refine stent designs, optimize degradation profiles, and enhance overall efficacy and safety in airway management.