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Digital Microfluidic Biochips (DMFBs) precisely control droplets on an electrode array, making them vital for healthcare. However, they are vulnerable to numerous security threats, including structural modifications during the design phase, material vulnerabilities in manufacturing, and code-level cyber-physical attacks. These risks encompass microstructural changes, chemical tampering, and manipulation of bioprotocols. This study experimentally demonstrates these attacks on a commercial DMFB and proposes using the optical coherence tomography (OCT) technique as a countermeasure to detect structural and material anomalies, along with hash-based techniques for code-level defense.

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Attacks and Countermeasures for Digital Microfluidic Biochips

  • 会议论文

  • 发表日期：

    2025年

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  • Navajit Singh Baban,
  • Prithwish Basu Roy,
  • Pauline John,
  • Azhar Zam,
  • Sukanta Bhattacharjee,
  • Yong-Ak Song,
  • Ramesh Karri,
  • Krishnendu Chakrabarty

摘要

Digital Microfluidic Biochips (DMFBs) precisely control droplets on an electrode array, making them vital for healthcare. However, they are vulnerable to numerous security threats, including structural modifications during the design phase, material vulnerabilities in manufacturing, and code-level cyber-physical attacks. These risks encompass microstructural changes, chemical tampering, and manipulation of bioprotocols. This study experimentally demonstrates these attacks on a commercial DMFB and proposes using the optical coherence tomography (OCT) technique as a countermeasure to detect structural and material anomalies, along with hash-based techniques for code-level defense.